584 Novel Methods of Detecting Tumour Margins in Gastrointestinal Cancer Surgery

Abstract Aim Gastrointestinal (GI) cancers account for 26% of global cancer incidence with prevalence projected to rise exponentially due the ageing population and lifestyle choices. Surgical resection is mainstay treatment remove in its entirety achieve an R0 resection. Positive margins, when cancerous tissue has been left situ, associated increased morbidity mortality. Current margin assessment involves histopathological analysis, after specimen. Diffuse Reflectance Spectroscopy (DRS) Hyperspectral Imaging (HSI) are novel imaging techniques that have potential provide real-time margins intra-operatively reduce positive improve patient outcomes. The aim this review assess current state evidence use GI assessment. Method A literature was conducted studies using DRS HSI adult patients, published from inception October 2020. Results total 15 were analysed, nine which used six majority performed ex-vivo. image acquisition processing algorithms vary greatly. sensitivity specificity ranged 0.90-0.98 0.88-0.95 respectively 0.63-0.98 0.69-0.98, across five types cancers. Conclusions techniques, currently their infancy but outlook promising. With further research focused on standardising methodology in-vivo settings, could transform intra-operative